Research reviews
Editorial reviews of published research on insulin resistance and metabolic health, with post-publication context added.
- A 2026 Re-examination: DiNicolantonio and O'Keefe on Sodium Restriction and Insulin Resistance
A look back at the 2023 review arguing that low-salt diets worsen insulin resistance, what the broader cardiovascular and sodium-substitution evidence has shown, and how the specific mechanistic claim sits within the wider sodium-and-health debate.
- A 2026 Re-examination: Pateguana and Janes on Hyperinsulinemia and PCOS Hyperandrogenism
A look back at the 2019 review proposing that hyperinsulinemia drives the hyperandrogenism of polycystic ovary syndrome, what the 2023 international PCOS guidelines have validated, and how the treatment landscape has changed.
- A 2026 Re-examination: Malhotra, Schofield, and Lustig on Sugar Policy and Industry Opposition
A look back at the 2018 commentary on sugar reduction as public health policy, what subsequent natural experiments and meta-analyses have shown, and where the broader framing requires careful reading.
- A 2026 Re-examination: Lowery et al. on Soluble Corn Fibre and Isomaltooligosaccharides
A look back at the 2018 study on two dietary fibre alternatives, what subsequent research and the FDA's 2018 regulatory decision on isomaltooligosaccharide have shown, and what readers should know about industry-adjacent fibre research.
- A 2026 Re-examination: Cucuzzella et al. on Low-Carbohydrate Diets for Metabolic Syndrome Reversal
A look back at the 2017 community-based survey on real-world low-carb outcomes, what subsequent clinical trials have confirmed, and where the evidence remains complicated.
- A 2026 Re-examination: Ku, Ramos, and Fung on Therapeutic Fasting for Type 2 Diabetes
A look back at the 2017 case study on supervised intermittent fasting in insulin-dependent type 2 diabetes, what subsequent research has confirmed, and what remains in dispute.
- A 2026 Re-examination: Sampson, Bikman, and Colleagues on β-Hydroxybutyrate and β-Cell Function
A look back at the 2017 cell biology study on ketones and pancreatic beta-cell mitochondrial function, what subsequent mechanistic research has confirmed, and the limits of in vitro work for clinical translation.
- A 2026 Re-examination: Fung and Berger on Hyperinsulinemia and Insulin Resistance
A look back at the 2016 foundational editorial that framed hyperinsulinemia as the upstream driver of insulin resistance, what subsequent research has supported, and where the conceptual debate remains active.
- A 2026 Re-examination: Unwin, Haslam, and Livesey on Glycemic Response and Diabetes
A look back at the 2016 primary-care report on glycemic index as a practical tool for type 2 diabetes management, what subsequent peer-reviewed evidence has confirmed, and how continuous glucose monitoring has refined the underlying picture.
- A 2026 Re-examination: DiNicolantonio, Bhutani, and O'Keefe on Added Sugars and Chronic Kidney Disease
A look back at the 2016 comprehensive review linking dietary fructose and added sugars to chronic kidney disease pathogenesis, what subsequent mechanistic and clinical research has confirmed, and how the mainstream nephrology position has shifted.
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